Clotrimazole cream 1 instructions for use. Clotrimazole cream - application features for men and women, the secret of effectiveness

In our time, no one is protected from such a scourge as a fungus; everyone, without exception, can catch this disease. Perhaps he already lives in your body, but the body's defenses successfully suppress its development.

However, at the slightest failure in the immune system, harmful microorganisms can become activated and lead to unpleasant consequences. Clotrimazole ointment will help to quickly and painlessly say goodbye to the fungus. This effective tool should be kept in every first aid kit.

The composition of the ointment Clotrimazole

The composition of this drug includes the active substance clotrimazole, which has antifungal properties, as well as the following auxiliary components:

• propylene glycol;
• polyethylene oxide 400;
• polyethylene oxide 1500;
• methyl parahydroxybenzoate or methyl paraben.

The drug must be stored at a temperature of +5 to + 25 ° C, in a dry place out of the reach of children.

What ointment helps from: indications for use

This antifungal agent treats the skin and mucous membranes. The active substances of Clotrimazole penetrate the fungal cell and inhibit its development. After using the drug, the harmful cell accumulates a lot of hydrogen peroxide, which leads to its destruction.

This tool not only kills the fungus, but also helps to cope with pathogenic bacteria that adversely affect human health. The drug is used to treat various diseases of the legs, mucous membranes, skin caused by fungi:

• thrush;
• genital candidiasis complicated by trichomoniasis;
• dermatomycosis;
• paronychia;
• dermatophytosis;
• erythrasma, etc.

Also, this remedy is recommended for infection with a fungus that provokes microsporia and. Fungi are especially sensitive to the main active substance, and therefore are destroyed quickly enough. However, you should prepare for the fact that the treatment will take more than one week.

In addition, the ointment helps to cope with such a problem as skin pigmentation. Of course, Clotrimazole is primarily an antifungal agent. But despite this, he helped many people get rid of age spots. Also, the drug is effective for streptoderma and herpes.

Analogues of Clotrimazole ointment:

• Candide;
• Kanesten;
• Amyclone;
• Candibene.

How to use Clotrimazole ointment

The method of use for many diseases is the same - the ointment is applied 3-4 times a day in a small dose on dry and clean skin or mucous membranes. Rub the drug into the affected areas carefully and carefully. It is impossible to cover the treated areas with bandages.

Often, doctors advise using the ointment in combination with other drugs. For example, with thrush, only complex treatment will be truly effective - using ointment and vaginal suppositories.

The course of treatment with ointment can have a different duration, which depends on the form and stage of the disease. On average, you can focus on the fact that:

• Treatment of mycoses lasts at least a month. You can not interrupt the course even in the absence of visible signs of the disease. Sometimes doctors advise continuing to use the ointment for another 2-3 weeks after treatment for preventive purposes.
• Foot fungus must be treated for another two weeks after the symptoms have completely resolved.
• Lichen is treated for three weeks or more.
• Mild forms of thrush pass quite quickly - in 7-10 days.

How to use for thrush

Thrush is a common disease that affects both women and men. With candidiasis, it is recommended to use the ointment 2 times a day, treating the areas affected by the fungus with the agent.

Women should apply the ointment when the first symptoms appear, such as: itching and irritation in intimate places, a feeling of swelling, copious cheesy discharge, and burning when emptying the bladder.

With thrush, the vagina must be lubricated once a day with a thin layer of ointment, gently rubbing it in a circular motion. If the disease is chronic, then the drug should be applied not once, but three times a day. Approximate dosage - 5 gr. The duration of treatment is determined by the doctor. During the application of the ointment, you can not have sex. In the presence of the disease, both partners are treated. Clotrimazole for men is applied twice a day to the head and foreskin of the penis.

From nail and foot fungus

Small doses of Clotrimazole inhibit the development of mycosis, and large doses completely destroy it. Before proceeding to the use of the medication, it is necessary to wash the affected area with laundry soap and a solution of baking soda, and then dry it thoroughly.

The ointment must be applied in a thin layer on the affected areas 3 times a day. Treated areas must not be covered. After 5 days, you can notice the first signs of healing, but you should not interrupt the treatment. As a rule, treatment lasts 4-8 weeks. To make sure of your full recovery, you must pass the appropriate tests.

For the treatment of lichen

Clotrimazole ointment is used to treat pityriasis (color, multi-colored) lichen. This disease is caused by yeast. These microorganisms are opportunistic pathogens, i.e. they can live in the body of a healthy person, but do not cause any disturbance. However, certain factors can provoke uncontrolled reproduction of fungi, which will lead to the development of colored lichen.

With this disease, the ointment is applied to the affected areas 2-3 times a day for 2-4 weeks.

Can it be used during pregnancy and lactation

There is no evidence that the ointment can cause disturbances in the embryonic development of the fetus, however, the appropriateness of using this drug should be determined by the doctor on an individual basis. It is impossible to treat mammary glands with Clotrimazole during breastfeeding and lactation.

Contraindications and side effects

The ointment can not be used with increased sensitivity of the patient to its components and in the first three months of pregnancy. It is not recommended to apply the ointment for wet inflammations - in this case, it is better to resort to a cream with the same name, since it has drying properties.

With caution, the ointment is taken in the second and third trimester, as well as for problems with the liver.

Usually the drug is well tolerated by patients, but in some cases, side effects in the form of itching and irritation are possible. Swelling, peeling, redness may appear on the skin. In this case, the doctor determines the advisability of further use of the drug.

If an allergy in the form of urticaria appears on the skin after using Clotrimazole, then treatment should be immediately interrupted.

The drug clotrimazole has various forms of release. Candles, solutions, creams, gels and ointments. The ointment form is the most popular.

Compound

Ointment contains clotrimazole, in the amount of 1 gram.

In addition to it, the composition includes excipients:

• propylene glycol;
• polyethylene oxide 400;
• polyethylene oxide 1500;
• methyl parahydroxybenzoate or methyl paraben.

Operating principles

is a substance from the group of imidazole derivatives. It acts on fungal organisms as a poison, disrupting their vital processes. Clotrimazole inhibits the synthesis of ergosterol, a structural component of fungal cells, which leads to their gradual destruction.

Since the ointment is poorly absorbed, the substance accumulates in the upper layers of the skin, which leads to an increase in the detrimental effect on pathogenic fungal organisms.

In sufficiently high doses, the drug also has an additional toxic effect on the cells of the fungus, increasing the concentration of hydrogen peroxide in them, and accelerating the process of their destruction.

The drug is active against the following pathogenic fungi:

• dermatophytes;
• yeast fungi;
• moldy fungi;
• causative agents of multi-colored lichen and erythrasma.

It has a weak antimicrobial effect against some gram-positive and gram-negative bacteria.

Clotrimazole ointment is absorbed into the skin and mucous membranes. The substance is concentrated in the epidermis and in the keratin of the nails, almost not penetrating into the lower layers of the skin and practically not getting into the bloodstream.

Indications for use

The drug is used to treat various diseases of the legs, mucous membranes, skin caused by fungi:

• thrush;
• stomatitis;
• genital candidiasis complicated by trichomoniasis;
• superficial candidiasis;
• dermatomycosis;
• paronychia;
• dermatophytosis;
• erythrasma;
• mycoses complicated by infection of pyogenic cocci.

Ways to use Clotrimazole

First of all, you need to prepare the affected area:

• Clean it with soap and water and wipe dry;
• Soap should be used soft, such as baby soap, because the alkaline environment reduces the effectiveness of the drug;
• Skin with a disturbed acid-base balance has an increased risk of an allergic reaction to the ointment;
• The towel, after wiping, must be disinfected, for example, boiled.

The medicine is applied 2-3 times a day, based on: a column of ointment, half a centimeter in size, on a skin area the size of a palm. It is also recommended to treat 1 cm of healthy skin around the affected area to prevent the spread of infection.

Treatment of thrush

Thrush (candidiasis) is a disease caused by pathogenic yeasts of the genus Candida. Usually occurs in the genital form, causes itching, more often in women and less often in men. sometimes it can affect other mucous membranes, such as the oral cavity. Clotrimazole is often prescribed for the treatment of thrush.

The use of Clotrimazole in female thrush:

• It is necessary to take a supine position, bend your knees, and inject a sufficient amount of the drug into the affected organ;
• For convenience, it is recommended to use a special applicator;
• Then, you need to lie down for at least half an hour so that the product is evenly distributed and absorbed;
• It is also necessary to process the external genitalia;
• To avoid stains on clothes, you can use panty liners, without fragrances;
• Since the ointment is poorly distributed over the surface of the skin, in the case of vaginal candidiasis, it is preferable to use other forms of the drug, such as cream or suppositories;
• The duration of treatment is up to one month.

The use of Clotrimazole for male thrush (candidal balanoposthitis):

If one of the sexual partners has thrush, treatment should be carried out in both. Even if one of them does not have visible symptoms of the disease, preventive therapy is prescribed.

Treatment of nail fungus and feet

• Apply the ointment not only to the foci of infection, but also to the skin of the finger;
• Rub gently;
• After applying the medicine in the area of ​​​​the feet, you can wear socks made of natural fabric - cotton or linen;
• In order to avoid a new infection, it is recommended to treat the inner surface of the shoe with Clotrimazole;
• , special solutions of the drug are more suitable, because interact with the nail plates better than ointment;
• Nails, in case of illness, need to be cut short, and the drug is better absorbed if they have a rough surface;
• Usually, to cure this form of fungus, you need a course of Clotrimazole, lasting from 4 to 8 weeks + 1 week of prevention.

Lichen treatment

The drug is suitable for:

• multi-colored (pityriasis) lichen;
• ringworm.

How to apply:

Treatment of dermatitis

It can be caused by both fungal infections and other causes.

There are three forms of this disease in which clotrimazole is often prescribed:

• seborrheic;
• atopic;
• diaper.

Application for seborrheic dermatitis

causes a fungus of the genus Malasesia, and treatment with antifungal agents is indicated here in any case.

Clotrimazole is used for seborrheic dermatitis on the face 3 times a day, on the head - 2 times a day.

For children, it is enough to apply the medicine once a day.

Use in atopic dermatitis

is an allergic disease, but can also be complicated by a fungus as a result of infection when scratching the skin.

Clotrimazole, in this case, is well suited, because. has additional antibacterial properties.

Usually prescribed in combination with other drugs.

For diaper dermatitis

Diaper dermatitis is an irritation of the skin in babies as a result of wearing diapers or constant swaddling, as the dense fabric does not breathe well and causes sweating.

May be complicated by candidiasis, as the fungus loves a moist, warm environment.

Usually the disease disappears after a week of applying the ointment. The ointment has low absorption, so its overdose is almost impossible.

It is desirable after the procedure that the baby has a glare for at least 10 minutes.

It is possible to prescribe additional drugs of different effects, depending on the specifics of the disease.

Use during pregnancy and lactation

Clotrimazole is not used in the first trimester of pregnancy. During the second and third trimester, the use of the drug is possible, with the permission of the doctor.

During lactation, you can not apply the medicine directly to the nursing breast.

Application in childhood

The drug can be prescribed to children, even newborns. For example, with diaper fungal dermatitis.

But with some restrictions:

• The skin of a child is involved in the process of breathing more actively than that of an adult, therefore it is not recommended to apply the medicine to large areas of the skin;
• Large foci of infection are treated in parts, alternately, 2-3 times a day;
• The ointment is suitable only for those types of fungal infection that are accompanied by drying of the skin.

For infected diaper rash in infants, Clotrimazole is used in the form of powders.

Contraindications

There are several contraindications:

• Hypersensitivity to the components of the drug;
• First trimester of pregnancy;
• The presence of wounds and abrasions on the skin;
• The presence of erosions of the mucous membranes;
• Intravaginal use during menstruation is unacceptable.

Side effects

In rare cases, the drug can cause:

• burning;
• tingling in treated areas;
• edema;
• erythema;
• redness;
• peeling of the skin.

In such cases, the drug is canceled.

special instructions

• Clotrimazole is not used for fungal eye diseases;
• Do not apply ointment to the skin around the eyelids;
• In case of contact with eyes, rinse with water;
• After applying Clotrimazole, occlusive dressings should not be applied;
• If after 3 days of treatment with the drug no improvement is observed, the correctness of the diagnosis should be checked;
• In liver failure, it is necessary to monitor the work of the liver;
• Clotrimazole preparations are not intended for internal use;
• May cause poisoning if swallowed. In such cases, you need to take activated charcoal and consult a doctor;
• After using the drug, wash your hands with soap;
• Keep away from children.

Overdose

The use of ointment in high doses does not pose a danger to life.

Interaction and incompatibility with other drugs

Simultaneous use of the drug with Amphotericin B, Nystatin, Nitamycin is unacceptable. they reduce the effectiveness of clotrimazole.

Terms and conditions of storage

In a dry, dark place at a temperature of 15 to 25 degrees Celsius.

Avoid freezing. Store in a place protected from children.

Price

The average price of Clotrimazole ointment in Russia: 42 rubles .

The drug Clotrimazole cream is used for pathologies caused by a fungus, for example, vaginal candidiasis or thrush. The main active substance of the agent destroys the membranes of fungi and has a detrimental effect on pathogenic microorganisms. Due to the low price and positive reviews, this anti-fungal drug is one of the leaders in the pharmacological market.

What is clotrimazole cream

For fungal diseases of the skin, nails, vaginal candidiasis (thrush), drug therapy is prescribed with antibacterial ointment Clotrimazole (clotrimazole). The drug has a strong antifungal effect on pathogens of erythrasma, fungal psoriasis and other common mycotic diseases. The doctor can prescribe an ointment at the first symptoms of infection, for the prevention of mycosis in the layers of the skin and on the vaginal mucosa.

The drug inhibits the growth, development and division of fungal cells. In addition, the drug is widely used for infections of the genital tract (for example, with vaginal mycosis of the vaginal membrane). For the treatment of candidiasis, the ointment is prescribed to both sexual partners. In this case, it is recommended to apply the cream both before sexual intercourse and immediately after it.

The drug in the form of a cream is a mass of pale yellow color, the consistency of fatty sour cream, packed in an aluminum tube and a cardboard box with an annotation for the drug, instructions for using the antifungal drug. Clorimazole ointment is available for sale in pharmacies and online stores without a doctor's prescription.

Compound

The drug is available in several dosage forms: vaginal tablets, suppositories, ointment, cream for external use. The latter has the following composition:

1. The main active ingredient is clotrimazole 10 mg.
2. Additional substances - ethyl alcohol, petroleum jelly, glycerol, distilled water, solid fat.

pharmachologic effect

The drug disrupts the synthesis of ergosterol, which is part of the membrane of fungal cells. Clotrimazole inhibits the processes of cell division of pathogenic microorganisms and is one of the most effective antifungal agents, since it has a wide spectrum of action. The drug has a detrimental effect on gram-positive and gram-negative bacteria. Doctors recommend starting therapy at the first sign of an infection.

Why clotrimazole

Cream with clotrimazole has the following indications for use:

• fungal diseases of the skin;
• mycoses of the feet, palms, skin folds;
• pityriasis versicolor;
• thrush;
• erythrasma;
• superficial and deep candidiasis.

Instructions for use Clotrimazole cream

The drug Clotrimazole is used for external application in antifungal therapy. The medication, according to the instructions, is applied in a thin layer 2-3 times / day. on clean and dry skin areas with affected epidermis. If the skin has serious lesions and ulcers, to achieve the best effect, it is recommended to use compresses with cream for several days so that the drug is absorbed in high concentrations. The duration of the course of therapy depends on the severity of the disease, the localization of the pathology, and effectiveness.

For women

A drug with antifungal activity Clotrimazole is used for women suffering from frequent exacerbations of thrush, vaginitis and other bacterial lesions of the vagina. The duration of the course of treatment is from 5 to 10 days, depending on the severity of the disease. Clorimazole is recommended to be used to prevent exacerbations of candidiasis during colds and reduce overall immunity. The drug should be used with caution during menstruation.

For men

Cream with clotrimazole for men is used mainly for the treatment of chronic and acute forms of candidal skin lesions of the genitals. Treatment of fungal diseases in men lasts from 4 to 7 days. It is better to start using the cream when the first signs of the disease appear: severe itching, burning, redness, pain during urination. Careful hygiene of the genitals also helps. Do not use the cream in case of hypersensitivity to the components of the drug.

drug interaction

Some drugs (Amphotericin B, Nystatin) significantly reduce the effectiveness of Clotrimazole with simultaneous drug therapy, so they do not need to be used together. When using the drug, negative interactions with other drugs as a result of clinical studies have not been identified. With caution, you should use the cream at the same time as other antibiotic ointments, since the combination of different groups of antifungal drugs can lead to allergies.

Side effects and overdose

When using a cream with Clotrimazole, local side reactions are often noted: itching, burning, redness of the skin at the site of application of the drug. In some cases, blisters, erythema, swelling and peeling of the skin appear. Individual intolerance to the drug is manifested by urticaria. The use of the drug in high doses does not cause life-threatening and health conditions.

Contraindications

The use of Clotrimazole is categorically contraindicated if the patient has a history of:

• insufficiency of the kidneys or the urinary system as a whole;
• hypersensitivity to the components of the drug;
• insufficiency of the liver;
• open wounds on the skin;
• allergic reactions.

special instructions

The antibiotic Clotrimazole is intended strictly for external use in fungal infections and other skin diseases. The drug is not suitable for use in ophthalmic practice, contact of the cream with the eyes and the skin around them should be avoided. With caution, the drug is used in children under 5 years of age. Do not allow the cream to get into open wounds, on damaged mucous membranes. When the first signs of an allergic reaction appear, drug therapy with the drug must be discontinued.

Pregnancy and lactation

No toxic effects of the drug on the fetus have been identified, the use is relatively safe at all stages of pregnancy. Therapeutic doses of the drug do not affect the development of the fetus. It is recommended to use Clorimazole to prevent fungal infections in women in the first trimester of pregnancy who have an unfavorable permanent environment (for example, if a girl works in a kindergarten or medical institution). Use during breastfeeding is not prohibited if the cream does not enter the mammary glands.

Analogues

A large number of drugs are presented on the pharmacological market, which are similar in their action to Clotrimazole, but differ in the form of release, price, and composition. Some of them may cause fewer side effects or work faster. The main analogues of Сlotrimazole are:

1. Candide. An antifungal drug that has a wide spectrum of action against fungal microorganisms. The main active substance of Candida - clotrimazole - is a form of the substance imidazole. Due to the fact that the drug damages the membranes of fungal cells, according to reviews, it is considered one of the best antifungal agents. The cost of the medicine is about 80 rubles.
2. Canison. The drug has fungistatic and fungicidal effects, the manifestation of which depends on the doses of the drug used. The following groups of fungi are sensitive to Canizon: dermatophytes, moldy fungi, blastomycetes and dysmorphic fungi, actinomycetes. The active ingredient inhibits the synthesis of molecules of the substance ergosterol, which is necessary for the formation of cell membranes of pathogenic microorganisms. The price of the drug is on average from 75 rubles per pack.

Price

Before buying a drug, it is advisable to find out how much Clotrimazole costs, compare prices, choose the lowest one. You can order the drug in the online store according to the proposed catalog. The cost of Clotrimazole depends on several factors:

• percentage of the active active substance;
• clotrimazole concentrations;
• nature and quality of additional ingredients;
• manufacturer.

Video

Compound

1 g of cream contains:

active substance: clotrimazole 0.01 g

Excipients: benzyl alcohol, cetostearyl alcohol, octyldodecanol, polysorbate 60, sorbitan stearate, synthetic cetaceum (ester cetyl wax), purified water.

Description

Homogeneous mass of white.

Pharmacotherapeutic group

Antifungal agents for external use. Derivatives of imidazole and triazole. The codeATX: [ D01 AC01] .

pharmachologic effect

Clotrimazole inhibits cell growth and division and, depending on the concentration, may have a fungistatic or fungicidal effect. Clotrimazole changes the permeability of the cell membrane by disrupting the synthesis of ergosterol and binding to the phospholipids of the fungal cell wall. Clinical studies have shown that topical treatment of infections with clotrimazole is as effective as other imidazole derivatives such as econazole and ketoconazole.

Clotrimazole inhibits the synthesis of proteins, fats, DNA and polysaccharides, damages cellular nucleic acids and accelerates the excretion of potassium. It can also inhibit the activity of oxidases and peroxidases and the biosynthesis of triglycerides and phospholipids in fungi. At higher concentrations, clotrimazole causes damage to cell membranes through mechanisms independent of sterol synthesis. Clotrimazole prevents the transformation of Candida blastospores albicans into an invasive mycelium. A change in the activity of the cell membrane leads to cell death and depends on the degree of exposure of the drug to microbial organisms.

Activity spectrum

Clotrimazole is characterized by a wide spectrum of activity. Clotrimazole inhibits the development and destroys dermatophytes (Epidermophyton floccosum, microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum), yeast (Candida spp., Cryptococcus neoformans) and dimorphic fungi (Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis). Also, clotrimazole is active against some gram-positive (Streptococcus, Staphylococcus, Gardnerella vaginalis) and gram negative (Bacteroides) microorganisms.

In vitro clotrimazole inhibits reproduction Corynebacterium and gram-positive cocci (with the exception of enterococci) at concentrations of 0.5-10 µg/ml.

Clotrimazole has a wide spectrum of fungistatic and fungicidal activity in vitro. Its effect on the mycelium of dermatophytes (Trichophyton, microsporum, Epidermophyton) similar to the action of griseofulvin, and the effect on budding fungi (Candida) similar to the activity of polyenes (amphotericin B and nystatin).

Clotrimazole at a concentration below 1 μg / ml inhibits the development of most strains Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and microsporum canis. Clotrimazole at a concentration of 3 μg / ml inhibits the development of most pathogens Pityrosporum orbiculare, Aspergillus fumigatus, Candida species, including Candida albicans, some strains Staphylococcus aureus and Streptococcus pyogenes, as well as some strains Proteus vulgaris and Salmonella. Clotrimazole works against Sporothrix, Cryptococcus, Cefalosporium and Fusarium. Concentrations above 100 µg/ml are effective against Trichomonas vaginalis.

Mushrooms resistant to clotrimazole are extremely rare; there is data only for individual strains Candida guilliermondii.

No development of resistance has been reported in clotrimazole-sensitive fungi after passage. Candida albicans and Trichophyton mentagrophytes. There are no cases of development of resistance to clotrimazole in strains FROM.albicans, resistant to polyene antibiotics due to chemical mutation.

Pharmacokinetics

When applied topically to the skin, clotrimazole is absorbed by the epidermis. Higher concentrations of clotrimazole are found in the horny and spinous layers of the epidermis, as well as in the papillary and reticular layers of the dermis, however, clotrimazole enters the systemic circulation in small quantities.

Clotrimazole is metabolized in the liver to inactive substances excreted from the body through the kidneys and intestines.

Indications for use

Clotrimazole cream is used for topical treatment

Fungal diseases of the skin: hands and feet, trunk, lower leg and foot, caused by dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and microsporum canis; pityriasis versicolor caused by Malassezia furfur (Pityrosporum orbiculare or Pityrosporum ovale) ;

Fungal infections of the skin and mucous membranes of the external genitalia (labia, foreskin and glans penis) caused by Candida vulvitis or Candida balanitis.

Contraindications

Hypersensitivity to clotrimazole or excipients of the drug.

Use during pregnancy and lactation

Pregnancy

There are limited data on the use of clotrimazole during pregnancy. Animal studies have not shown a direct or indirect effect on reproductive toxicity. As a precautionary measure, the use of clotrimazole in the first trimester of pregnancy should be avoided.

Lactation

Available pharmacodynamic/pharmacokinetic data in animals have shown excretion of clotrimazole/metabolites into milk. During treatment with clotrimazole, breastfeeding should be discontinued.

Fertility

Studies of the effect of clotrimazole on human fertility have not been conducted. Animal studies have shown no effect on fertility

Dosage and administration

For outdoor use.

The cream should be applied in a thin layer 2-3 times a day on previously cleansed (using neutral pH soap) and dry affected areas for 2-4 weeks.

The cream should be applied simultaneously to all affected areas.

When applying the cream on the feet, they must be thoroughly washed, dried, and then applied to the areas between the toes.

Patients should re-consult a doctor if symptoms do not improve after 7 days of treatment.

Side effect

The frequency of occurrence of adverse reactions is defined as follows: very often (≥ 1/10), often (from ≥ 1/100 to the frequency is unknown (frequency cannot be estimated from the available data).

Immune system disorders:

Frequency unknown: allergic reactions (such as urticaria, shortness of breath, arterial hypotension, fainting).

Skin and subcutaneous tissue disorders:

Frequency unknown: itching, rash, blisters, peeling of the skin, sensation of pain or discomfort, swelling, burning, irritation, erythema, tingling.

If the listed adverse reactions occur, as well as reactions not mentioned in the instructions for medical use, you should contact your doctor.

Overdose

With external use of the drug, an overdose is unlikely.

The use of clotrimazole in high doses does not cause any reactions and conditions that are life-threatening.

The drug is not intended for oral administration. If by chance the cream is taken orally, anorexia, nausea, vomiting, abdominal pain, liver dysfunction are possible; rarely drowsiness, hallucinations, frequent urination, allergic skin reactions. In this case, it is necessary to carry out a gastric lavage and prescribe activated charcoal.

In case of accidental contact of the cream with the eyes or mouth, immediately rinse them with water and consult a doctor as soon as possible.

If the cream is swallowed, you should immediately consult a doctor.

Content

To eliminate the causative agents of lichen, with fungal infections, the antibacterial drug Clotrimazole is prescribed - the instructions for use of which include information on the dosage and method of use. This medication with antimycotic action does not belong to antibiotics, but it has a detrimental effect on microorganisms. Familiarize yourself with the indications for its use, possible side effects described in the instructions.

clotrimazole for fungus

According to the pharmacological classification, Clotrimazole is included in the group of drugs with an antifungal effect and a wide spectrum of action. With it, you can eliminate signs of multi-colored lichen, fungal manifestations on the skin and mucous membranes of the genital tract. A remedy with an antimycotic effect is used topically, externally or intravaginally, has several different forms of release. It is approved for use by children and adults.

Composition and form of release

There are six forms of release of the drug: cream, ointment, gel, solution, vaginal suppositories and tablets. Check out the detailed composition of each medicine:

	clotrimazole concentration	Auxiliary components	Description	Package
	1 g per 100 g	Cetostearyl and benzyl alcohol, sorbitan stearate, octyldodecanol, polysorbate, water, synthetic spermaceti	White, uniform	Aluminum tube 20 g
		Monoglycerides, cetostearyl alcohol, castor oil, emulsion wax, polysorbate, glycerol, methyl and propyl parahydroxybenzoate, propylene glycol, water	White-yellowish with a slight odor	15 and 30 g aluminum tubes
	10 mg per 1 g	Ethyl alcohol, glycerol, macrogol, carbomer, sage extract, propylene glycol	Homogeneous transparent gel with sage aroma	20 and 40 g aluminum tubes
	10 mg per 1 ml	Ethanol, propylene glycol, polyethylene glycol	Clear colorless liquid	25 ml, glass bottles with applicators
Vaginal suppositories	100 mg per 1 pc.	Semi-synthetic glycerides	Cylindrical-conical shape, white-yellow color, on the cut there is an air rod or a recess in the form of a funnel	6 pcs. in blisters
Vaginal tablets		Magnesium stearate, adipic acid, lactose monohydrate, sodium bicarbonate, potato starch, sodium lauryl sulfate, colloidal silicon dioxide	white oblong	6 pcs. in blisters

Pharmacodynamics and pharmacokinetics

The main substance inhibits the growth and reproduction of microorganisms, has a fungistatic effect and fungicidal activity, and leads to the death of fungi. Due to the inhibition of the synthesis of ergosterol, the component binds to the phospholipids of the fungal cell membrane, changing its permeability. In high concentrations, clotrimazole damages fungal cells by lysis without suppressing the synthesis of ergosterol, prevents the formation of proteins, fats and polysaccharides of fungi, destroys their nucleic acids and increases the excretion of potassium.

The drug has a broad effect on dermatophytes, yeasts, dimorphic and mold fungi, protozoa, plus it destroys gram-positive bacteria. Fungistatic activity is manifested in relation to the mycelium of dermatophytes, budding fungi from the genus Candida. The component is practically not absorbed into the systemic circulation when applied to intact and non-inflamed skin. The concentration in blood serum is negligible, with intravaginal application, absorption is 3-10% of the dose. The drug breaks down in the liver to inactive metabolites, excreted by the kidneys and intestines.

From what ointment Clotrimazole

With external use of ointment, gel, cream and solution, according to the instructions, the following indications are distinguished:

• fungal diseases caused by dermatophytes, yeast-like fungi, mold pathogens sensitive to the active ingredient;
• mycoses of feet, brushes;
• candidal vulvitis, balanitis with the localization of the fungus inside the body;
• versicolor versicolor, erythrasma;
• skin mycosis;
• fungal infection of the outer ear.

When using intravaginal forms of the drug (solution, suppositories and tablets), the indications are:

• infections of the genital organs caused by yeast-like fungi of the genus Candida;
• vulvovaginal candidiasis;
• urogenital infections;
• trichomoniasis;
• genital superinfections caused by microorganisms that are sensitive to the active ingredient of the drug;
• sanitation of the birth canal before childbirth.

Method of application and dosage

The instructions and reviews say that Clotrimazole can be used vaginally or externally. The dosage, course of treatment and method of use depend on the type of disease, the individual characteristics of patients, their age and the type of pathogen. Cream, ointment and gel are often applied to the skin to eliminate fungal infections and lichen, tablets and suppositories are used intravaginally to treat urogenital candidiasis.

Clotrimazole cream

For external use, Clotrimazole cream is intended. According to the instructions, it is applied to dry clean affected areas up to three times / day. If the symptoms have already disappeared, it is recommended to continue treatment for another two weeks to prevent the occurrence of relapses. The cream is applied to the skin, washed with neutral acid soap, without a bandage, on the feet it is used between the toes. The course of treatment is:

• ringworm - up to 4 weeks;
• erythrasma - up to a month;
• multi-colored lichen - up to 3 weeks;
• candidal vulvitis - up to 2 weeks;
• the minimum duration is 3 weeks.

Gel

Clotrimazole gel is also used externally, on the skin. Apply it to the affected areas 2-3 times / day. According to the instructions, the minimum course of treatment will be 2-4 weeks. It is allowed to use the gel for the treatment of the oral cavity - up to two times / day for no more than a week. If the drug is prescribed for intravaginal administration, use 100-150 mg of Clotrimazole daily for 1-6 days.

Ointment Clotrimazole

According to the instructions, the ointment is applied in a thin layer 2-3 times / day on cleansed with neutral soap and dried skin. Gently rub the composition and leave until absorbed. The duration of therapy is:

• dermatomycosis - from a month;
• pityriasis versicolor - 1-3 weeks;
• at the end of the course, it is worth continuing treatment for another 2 weeks;
• with fungal infections of the nails of the feet - for 2-3 weeks.

Solution

Like the gel, Clotrimazole solution can be used externally to treat the skin and intravaginally to eliminate candidiasis pathogens. In the first case, the solution is applied to the affected dry areas up to three times / day for 0.5-1 month. To treat the mouth, rinses and applications with cotton swabs are intended twice a day for no more than a week. According to the instructions, intravaginal use of the solution should not exceed six days.

Candles Clotrimazole

For local use, suppositories with Clotrimazole are intended. According to the instructions, they are administered intravaginally by women and teenage girls. They are inserted into the vagina in the evening, very deep, lying on your back with bent legs. The course of treatment lasts six days - one suppository is inserted into the vagina into each of them. Repeated therapy is prescribed by the doctor after examination.

Clotrimazole tablets

Another form of release for intravaginal use is tablets. The course of treatment lasts 6-7 days, during which one tablet / day is prescribed, or three days, one tablet twice / day. If there is no effect within three days, the diagnosis is reviewed, and if after a week the treatment does not give a result, a medical consultation is required. Repeated therapy is possible, but increases the risk of detecting the pathology of diabetes mellitus or HIV infection.

If symptoms occur after a couple of months, the patient is sent to a doctor. It is allowed to combine tablets with cream for infection of the vulva. For complete dissolution of the first, it is necessary to create normal moisture in the vaginal mucosa, if it is dry, the tablet can stand out. To prevent this from happening, inject the tablet as deeply as possible. According to the instructions, treatment during menstruation is not carried out. If sanation is necessary, a woman is prescribed one tablet before childbirth.

special instructions

According to the instructions of the types of the drug, there are special instructions that must be followed when using them:

• Avoid getting the cream on the mucous membrane of the eyes, do not ingest.
• Treat infected areas at the same time, for vaginal lesions, treat the male partner in the same way.
• Cetearyl alcohol may cause contact dermatitis.
• If sensitivity or skin irritation occurs, therapy is stopped.
• Contraceptives containing latex are destroyed by the active substance - alternative drugs should be used after five days after treatment.
• There is no data on the effect of the drug on the speed of psychomotor reactions.
• It is necessary to control the functional state of the liver in patients with liver failure.

During pregnancy

The use of the drug is indicated for pregnant women only on prescription, if the latter evaluates the benefit to the mother above the risk to the fetus. Epidemiological studies have not revealed any violations in the course of bearing a child or his health when using the drug. There are no data on the effect of the drug on fertility. Candles are contraindicated in the first trimester of pregnancy.

In childhood

For the treatment of fungal diseases in children, you can use a cream, ointment and clotrimazole solution. The dosage goes according to the instructions, does not differ from adults. Vaginal tablets are allowed to be used from the age of 12. Indications for use:

• Treatment of oral candidiasis. 10-20 drops of the solution are applied to a cotton swab and the affected areas are wiped 3-4 times / day, the course lasts until the symptoms disappear completely (approximately 2-3 days).
• Fungal lesions of the skin, mucous membranes, nail fungus. Cream or ointment is used 1-3 times / day.

drug interaction

The instructions for use of the drug indicate its interaction with other medicines:

• Amphotericin, Nystatin and Natamycin reduce the effectiveness of Clotrimazole, except for the ointment format that acts in the layers of the epidermis.
• The vaginal combination of Clotrimazole and oral tacrolimus (an immunosuppressive drug) increases the concentration of the latter in the blood plasma, requires careful monitoring of patients.

Side effects

Depending on the use of different forms of release of Clotrimazole, the following side effects are indicated in the instructions:

• allergic reactions, urticaria, syncope, arterial hypotension, shortness of breath;
• rash, itching on the skin, peeling, pain, swelling, irritation, burning;
• discharge, itching, burning and swelling of the vaginal mucosa;
• headache, abdominal pain;
• frequent urination;
• the appearance of blisters;
• cystitis;
• pain during intercourse, burning of the partner's penis.

Overdose

Symptoms of accidental ingestion of the drug inside are dizziness, vomiting, nausea. Treatment is symptomatic. With external use, an overdose is unlikely. When using vaginal forms of Clotrimazole in an amount exceeding the recommended one, the manifestation of a dangerous condition is impossible. When swallowing tablets or suppositories, drowsiness, hallucinations, vomiting, anorexia are possible. To eliminate symptoms, patients are given activated charcoal. There is no specific antidote.

Contraindications

According to the instructions, contraindications for the use of the drug are as follows:

• Hypersensitivity to components.
• First trimester of pregnancy, menstruation when using suppositories.
• With caution, the drug is used during breastfeeding, in the first case of vaginal candidiasis.
• For tablets - age up to 12 years; more than two cases of thrush in the last six months; the presence of sexually transmitted diseases in history; pregnancy; age over 60; hypersensitivity to imidazoles.
• It is forbidden to use tablets for bleeding from the vagina, uterine hemorrhages, ulcers, blisters on the vulva. Do not use them for dysuria, fever or diarrhea, vomiting, pain in the back and shoulders.

Terms of sale and storage

The cream is dispensed in pharmacies by prescription, other forms - without it. Storage conditions: dry clean place out of reach of children. Shelf life: cream, suppositories and tablets - 3 years, ointment - 2 years.

Analogues

According to the active substance and pharmacological action, the following analogues of Clotrimazole are distinguished, produced in the form of a cream, tablets, solution and suppositories:

• Candide;
• Canison;
• Imidil;
• Candibene;
• Kanesten;
• Ganesten;
• Lotrimin;
• Mycosporin;
• Panmikol;
• Alokandp;
• Antifungol;
• Dignotrimanol;
• Faktodin;
• Funginal;
• Ginelotrimine.

Clotrimazole price

The cost of the drug depends on the form of its release, the margin of the seller and the cost of the manufacturer. You can buy Clotrimazole via the Internet or in a familiar pharmacy. Approximate prices in Moscow are as follows.