Vit e tocopherol acetate. Vitamin E

17.08.2020

- α-tocopherol acetate (tocopherol)

Composition and form of release of the drug

Excipients: sunflower oil 30 mg.
Capsule shell: gelatin 112.225 mg, glycerol 85% 62.397 mg, methyl parahydroxybenzoate 0.112 mg, crimson dye (Ponso 4R E124) 0.499 mg, purified water 74.768 mg.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - packings are cell planimetric.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (50) - packs of cardboard.
10 pieces. - cellular contour packings (100) - packs of cardboard.
10 pieces. - cellular contour packings (200) - packs of cardboard.

pharmachologic effect

It has an antioxidant effect, participates in the biosynthesis of heme and proteins, cell proliferation, tissue respiration, and other important processes of tissue metabolism, prevents hemolysis of erythrocytes, prevents increased permeability and fragility of capillaries.

Pharmacokinetics

When taken orally, absorption is 50%; in the process of absorption, it forms a complex with lipoproteins (intracellular carriers of tocopherol). Bile acids are required for absorption. It binds to alpha 1 and beta lipoproteins, partially to serum. If protein metabolism is disturbed, transport is hindered. Cmax is reached after 4 hours. It is deposited in the adrenal glands, pituitary gland, testes, adipose and muscle tissue, erythrocytes, and liver. More than 90% is excreted in the bile, 6% - by the kidneys.

Indications

Hypovitaminosis, conditions of convalescence after diseases occurring with a febrile syndrome, high physical activity, old age, diseases of the ligamentous apparatus and muscles. Climacteric vegetative disorders. with overwork, asthenic neurasthenic syndrome, primary muscular dystrophy, post-traumatic, post-infectious secondary myopathy. Degenerative and proliferative changes in the joints and ligaments of the spine and large joints.

Contraindications

Hypersensitivity to tocopherol.

Dosage

Usually prescribed 100-300 mg / day. If necessary, the dose can be increased to 1 g / day.

Side effects

Maybe: allergic reactions; when taken in high doses -

Alpha-tocopherol acetate (vitamin E) is a drug that has an antioxidant effect, is involved in cell proliferation, protein and heme biosynthesis, in tissue respiration and other important processes of tissue metabolism, prevents increased capillary fragility and permeability, and prevents erythrocyte hemolysis.

Release form and composition

The drug is produced in the form of capsules and an oil solution for oral and intramuscular injections.

Each capsule contains 100 mg of α-tocopherol acetate, 1 ml of solution contains 50, 100 or 300 mg of vitamin E.

Indications for use of alpha-tocopherol acetate

As indicated in the instructions for alpha-tocopherol acetate, this vitamin preparation is prescribed for hypovitaminosis E and an increased need for vitamin E in the body, including:

premature newborn;
Young children with insufficient intake of this vitamin from food;
With peripheral neuropathy;
With diseases of the ligamentous apparatus and muscles;
With abetalipoproteinemia;
Patients with chronic cholestasis;
Patients with cirrhosis of the liver;
With gastrectomy;
With atresia of the biliary tract;
With Crohn's disease;
Patients with obstructive jaundice;
With celiac disease;
With tropical sprue;
Pregnant women (especially with multiple pregnancies);
People with nicotine and drug addiction;
During lactation;
With necrotizing myopathy;
With malabsorption;
Persons taking drugs designed to reduce the intake of cholesterol from food;
When taking mineral oils;
People on a diet high in polyunsaturated fatty acids;
During the period of convalescence after diseases that were accompanied by a febrile syndrome;
In old age;
With post-infectious and post-traumatic myopathy;
Women with menopausal autonomic disorders;
With overwork, neurasthenia;
Patients with primary muscular dystrophy;
People with degenerative and proliferative changes in the ligamentous apparatus of the spine and joints;
Men in violation of spermatogenesis and potency;
With skin diseases;
With epilepsy in order to increase the effectiveness of anticonvulsants.

Also, alpha-tocopherol acetate, according to the instructions, is prescribed to children born with low body weight in order to prevent the development of bronchopulmonary dysplasia, hemolytic anemia, malabsorption and complications of retrolental fibroplasia (a serious disease that affects the retina of premature babies and children with low weight).

Contraindications

According to the annotation to the drug, the only contraindication to the use of alpha-tocopherol acetate is hypersensitivity.

With caution, the vitamin should be taken by people with hypoprothrombinemia on the background of vitamin K deficiency, since when taking vitamin E in large doses (more than 400 IU), the disease may worsen. Under constant supervision, treatment with the drug should be carried out in patients with severe cardiosclerosis, an increased risk of thromboembolism and after myocardial infarction.

Method of application and dosage of Alpha-tocopherol acetate

Alpha-tocopherol acetate capsules are taken orally, the solution is either taken orally or injected intramuscularly.

The specific dosage and duration of the use of the vitamin is determined by the attending physician, taking into account the indications (prevention or treatment) and the severity of the patient's condition. As a rule, the daily dose is from 100 to 300 mg.

Side effects of alpha-tocopherol acetate

According to numerous reviews of people who have been treated with alpha-tocopherol acetate, in the vast majority of cases, the drug is well tolerated and does not cause any side effects if the dosage recommended by the doctor is observed. In extremely rare cases, allergic reactions may develop, which is usually due to hypersensitivity or intolerance to the drug. With intramuscular injection, soreness and infiltration at the injection site may be observed. When taking a vitamin in high doses, pain in the epigastric region and diarrhea are possible.

special instructions

With the simultaneous use of alpha-tocopherol acetate with cyclosponir, the absorption of the latter increases, and with dicumarol and warfarin, their effects may change.

People on a diet that is high in sulfur-containing amino acids and selenium may need to adjust their vitamin E dose down.

Alpha-tocopherol acetate enhances the effect of:

Antioxidants;
non-steroidal anti-inflammatory drugs;
Glucocorticosteroids;
Vitamins A and D;
Antiepileptic drugs, if an increased level of lipid peroxidation products is noted in the patient's blood;
Cardiac glycosides, and also reduces their toxicity.

When taking tocopherol in high doses, vitamin A deficiency may develop.

With the simultaneous use of alpha-tocopherol acetate at a dosage of more than 400 IU per day with anticoagulants, the risk of bleeding and hypoprothrombinemia increases.

Vitamin absorption is reduced by mineral oils, colestipol and cholestyramine.

The need for vitamin E increases in people taking iron supplements, as they increase the oxidative processes in the body.

Alpha-tocopherol acetate analogues

Structural analogs of alpha-tocopherol acetate are Vitamin E, Vitrum vitamin E, Enat, Evitol and Doppelherz vitamin E forte.

Also, α-tocopherol acetate is part of a variety of vitamin complexes.

Terms and conditions of storage

From pharmacies, the drug is dispensed without a doctor's prescription. Its shelf life is 2 years, subject to the storage rules recommended by the manufacturer - protected from direct sunlight, dry and cool (at a temperature of 15-25 ºС) place.

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There is a saying “vitamins are life”. Modern medicine does not deny this, because the lack of any substance can cause serious disruptions in the body. In this article, we will analyze what alpha-tocopherol acetate is, how its intake affects human health and the features of its use.

Alpha-Tocopherol acetate in its composition has:

active substance - vitamin E;
auxiliary component - refined sunflower oil.

Literally, "tocopherol" can be translated as "bearing offspring." In 1920, its reproductive role was first discovered. The experiment was carried out on rats: they were fed only skim milk, which contained a small amount of tocopherol compounds. Soon the rats stopped breeding. Also, scientists have noticed the death of the fetus in pregnant rats and a decrease in the amount of seminal epithelium in males.

Vitamin E has one feature: the body is not able to produce it on its own.. It can only be obtained with food and taking vitamin complexes. It was first synthesized from cereal oils in 1938.

In addition to the effect on the reproductive function of tocopherol acetate has other important functions for the human body. No wonder it is considered the main representative in the group of antioxidants.

Release form

Alpha Tocopherol Acetate is available as softgels, chewable lozenges, and oily solutions. There are also solutions for intramuscular injection. They are produced on the basis of peach and olive oils. Among the most common forms of release are:

dragee 100 mg;
oil solution in the form of capsules of 100, 200 and 400 mg;
50% solution for external use, produced in a glass jar;
5% and 10% solution for intramuscular injections.

Instructions for use are mandatory attached to all drugs.

The cost of the drug depends on its form of release. The price of capsules is about 20-30 rubles. The cost of a 30% solution is approximately 70 rubles.

Indications for use

Alpha-Tocopherol acetate is prescribed in the following cases:

Irritability and neurasthenia.
Violations of the function of the gonads in men.
Menstrual disorders.
Increased physical activity.
Fibrotic diseases of the breast in women.
Arthritis.
Psoriasis.
Seizures.
In case of living in special climatic conditions (highlands).
During puberty and during intensive growth.
Skin diseases (ulcer, eczema, dermatitis).
Vegetative disorders.
Eye diseases.
While taking hormonal drugs.
Hypervitaminosis of vitamins D and A.
During pregnancy, to reduce the risk of miscarriage and prevent abnormal fetal development.
lactation period.

The effect of the drug on the body

As noted above, vitamin E is one of the most powerful antioxidants. It is able to increase the resistance of cells to those substances that paralyze their work. Together with its "partner" vitamin C, tocopherol prevents the development of the peroxidation reaction and reduces the risk of cancer cells.

The effect of the drug is not limited to this. Vitamin E is needed by the circulatory system and all tissues of the human body. Alpha-Tocopherol acetate improves blood circulation and its clotting, saturates tissues with oxygen, restores the central nervous system, prevents blood clots and slows down fat oxidation.

This medication is used to normalize the reproductive system of men and women. It eliminates menstrual irregularities, restores sperm production and enhances sexual desire. In addition, Alpha-Tocopherol acetate has a beneficial effect on the growth of the fetus in the mother's womb, and also contributes to a surge of vitality in a pregnant woman.

The drug is also popular in cosmetology. It helps to cope with problems such as brittle hair and nails, dry skin.

Method of application and dosage

Many are interested in how to take the drug, because it is available in various forms. The method of application, dosage and course of taking Alpha-Tocopherol acetate depends on the disease and is determined strictly by the doctor.

The drug should be taken with food, drinking plenty of water. The usual daily dosage is 100-300 mg. As prescribed by the doctor, it can be increased to 1 g.

The instructions for use say that the duration of the course and the exact doses depend on the purpose of the reception:

For the prevention of hypovitaminosis, 100 mg twice a day is prescribed. The course is 1-3 weeks.
In the case of spermatogenesis, take 100-300 mg. The course is a month.
In case of violation of the menstrual cycle, 300-400 mg are prescribed. It is necessary to start taking from the 17th day of the cycle and so on for 5 cycles.
During pregnancy - 100 mg daily in the first trimester.
In diseases of the neuromuscular system, 100 mg is prescribed every day. The course lasts 1-2 months.
With neurasthenia, 100 mg should be taken every day. The course is 1-2 months.
For diseases of the skin, 100 mg daily is prescribed. The course is 20-40 days.

Side effects and contraindications

After taking Alpha-Tocopherol Acetate, some side effects may occur. These include:

pain in the abdomen, which is accompanied by diarrhea and nausea;
allergic reactions (itching, rash, urticaria, angioedema);
soreness and infiltration at the injection site.

Among the contraindications, individual intolerance is distinguished. Caution should be taken in the presence of the following diseases:

severe cardiosclerosis;
myocardial infarction;
vitamin K deficiency;
thromboembolism.

Medication analogues

Among the analogues of Alpha-Tocopherol acetate, the following can be distinguished:

Alpha-Tocopherol-UVB.
Biovital vitamin E.
Vitamin E-Slovakofarm.
Vitamin E Zentiva.
Vitrum vitamin E.
Doppelgerz Vitamin E forte.
Evion.

Vitamin E is a strong antioxidant that plays an important role in human health. It can only be obtained from the outside, that is, from products or multivitamins. An excellent way to replenish your vitamin E supply is to take Alpha-Tocopherol Acetate. Before use, be sure to read the instructions and consult with your doctor.

Products that say "vitamin E" on the packaging are on iherb a great variety. Some of them cost mere pennies, while others will have to pay a tidy sum. How to make the best choice for your health and wallet? How not to run into synthetic vitamin E and not overpay for the brand? How is Now Foods different from Solgar? I talk about all this in this article. Want to become a vitamin E expert - welcome!

What is vitamin E?

Vitamins of group E perform the function of antioxidants in the body, protecting cells from damage by free radicals.

Let's start with a small educational program and consider which substances belong to group E vitamins. I have prepared this little diagram for you so that everything is clear.

Here it is important for us to understand that vitamin E is not a single "homeless" molecule, but a whole group of natural compounds, the most important of which are tocopherols and tocotrienols. Both have 4 isomers - alpha, beta, delta and gamma.

Forms of Vitamin E

Alpha tocopherol

To date, in medical circles, the only active form of tocopherol that is designed to meet human needs is recognized alpha (or α-) tocopherol. In various sources, vitamin E most often refers to alpha-tocopherol.

The problem is that for a long time scientists did not study vitamin E at all, their goal was only to study alpha-tocopherol, one of the components of vitamin E. For example, a sensational 2005 study published in the Annals of Internal Medicine, which challenged the use of E reported a small increase in the risk of death associated with vitamin E supplementation. In this study, as in many others, only one component, alpha-tocopherol, was considered.

Numerous dietary supplements with the name "Vitamin E", produced by commercial companies, in fact turn out to be just alpha-tocopherol. More preferred forms of vitamin E will be discussed later in this article.

In many vitamin-mineral complexes, only alpha-tocopherol is present in vitamin E, and only in some - all 4 isomers of tocopherol. Tocotrienols are practically not found in vitamin-mineral complexes.

In the US, only an organization called the FNB (Food and Nutrition Board), which is part of the Institute of Medicine of the National Academy of Sciences, can officially recommend to mere mortals how much vitamin E should be taken in order to satisfy our needs in it. It is the strict uncles and aunts in white coats from FNB who install such a thing as an RDA. Even the DV (Daily Value) standards developed by the FDA are closer to RDA values.

Children:

1-3 years: 6 mg/day (9 IU)
4 - 8 years: 7 mg/day (10.4 IU)
9 - 13 years: 11 mg/day (16.4 IU)

Women:

Pregnant: 15 mg/day (22.4 IU)
Lactating: 19 mg/day (28.5 IU)

Men:

14 years and older: 15 mg/day (22.4 IU)

How did they calculate the RDA for vitamin E? By the level of alpha-tocopherol in the blood serum, which was sufficient to protect red blood cells from damage by hydrogen peroxide (free radical).

All daily recommended dosages of vitamin E are calculated specifically for alpha-tocopherol. The existence of other forms of vitamin E seems to be ignored by both the FDA and the Institute of Medicine. How much and what kind of vitamin E do we really need? About all this further and in order.

How to distinguish natural alpha-tocopherol from synthetic?

Natural alpha-tocopherol, derived from natural sources, is commonly displayed on food labels as " d-alpha-tocopherol". Synthetic (obtained in the laboratory) alpha-tocopherol, referred to as " dl-alpha-tocopherol". In general, the prefix "DL" or "dl" in the name of the active substance should suggest a synthetic form. The natural form of alpha-tocopherol is more bioavailable. For example, 100 IU of natural vitamin E corresponds to about 150 IU in synthetic form.

D-alpha tocopheryl acetate And d-alpha tocopheryl succinate are also considered to be natural forms of alpha-tocopherol that have undergone an esterification process to preserve the antioxidant properties of vitamin E (in order to produce vitamin E in dry form: tablets, powder). In the composition of vitamin-mineral complexes, d-alpha tocopheryl succinate is most often found.

Gamma tocopherol

While alpha-tocopherol rested on its laurels and was highly regarded for its antioxidant properties, its little-known younger cousin, gamma-tocopherol, remained underestimated, although it was equal, if not superior to alpha-tocopherol in its properties. Found in nuts, seeds, and vegetable oils, gamma-tocopherol makes up 70% of all vitamin E in the North American diet.

In April 2006, Life Extension Magazine featured an article titled "Why is gamma tocopherol preferred over alpha tocopherol?" which raised the issue that gamma tocopherol should be included in the nutritional guidelines set by the US Food and Nutrition Board.

Tocotrienols

Tocotrienols are the least explored half of the entire vitamin E group. Tocotrienols differ structurally from tocopherols and have important biological functions that tocopherols do not have.

Tocotrienols are considered more effective antioxidants than tocopherols, because due to the presence of a double bond, tocotrienols penetrate much more efficiently into the saturated fatty layers of the brain and liver.

The richest source of tocotrienols is annatto (fondant tree), red palm oil and wheat germ.

natural vegetable oils

Natural unrefined oils is the best and tastiest source of natural vitamin E. Which oils do I prefer?

Red Palm Oil by Nutiva- This is a fragrant, unrefined palm oil of bright orange color, rich in natural antioxidants - beta-carotene, tocotrienols and tocopherols. In a cool room, it freezes, if the room is hot, it becomes liquid. The manufacturer suggests using it for soups, sauces and stews. But I prefer to add it to porridge instead of cream, spread it on apple or pear slices, or just eat it with a spoon from a jar.

Now Foods Wheat Germ Oil- natural fragrant oil, not deodorized and not hydrogenated. Each tablespoon of NOW Wheat Germ Oil can contain over 1,000 mcg of naturally occurring Octacosanol. Octaconazole is considered one of the best sources of vitamin E. This oil is very tasty - it is pleasant to take it just like that or dress it with a salad.

Vitamin E supplements at iherb

Vitamin E products on iherb can contain one isomer (alpha-tocopherol only) or all eight. To find out which of the 8 isomers are in the product, you need to look at the Supplement Facts table.

Let's take a look at and analyze together a few foods that contain the full complex of vitamin E.

A complete vitamin E complex containing all 8 isomers, including 35 g of tocotrienols per serving, coenzyme Q10, alpha lipoic acid and vitamin C. Price - $11 for 30 servings/400 IU of vitamin E per serving. This is iHerb's most affordable and richest complex in tocotrienols.

Olympian Labs Inc., Tocomin Tocotrienol Vitamin E Complete, 60 Softgels - Also a complete vitamin E complex, but already contains 20 mg of tocotrienols per serving. The price is $30 for 60 servings/200 IU of alpha-tocopherol per serving.

Instructions for use:

Alpha-tocopherol acetate is a natural antioxidant and a fat-soluble vitamin.

Release form

Vitamin Alpha-tocopherol acetate is available in the form of lozenges, capsules, oil solution for intramuscular injections, oil solution for oral administration. The active ingredient is vitamin E.

pharmachologic effect

Vitamin Alpha-tocopherol acetate as an antioxidant prevents the development of free radical reactions, stops the formation of peroxides that are harmful to the full development of the human body, it is necessary for the normal functioning of the muscular and nervous systems. Vitamin E in combination with selenium inhibits the hemolysis of erythrocytes, prevents the oxidation of unsaturated fatty acids. Acts as a cofactor in some enzyme systems.

Vitamin E plays an important role in the functioning of the body. So, for example, it was noticed that in animals with a lack of vitamin E, irreversible changes are found in tissue structures, in the heart muscle and skeletal muscles, increased permeability and fragility of capillaries are observed. In embryos, due to a lack of vitamin E, hemorrhages occur, leading to intrauterine death. A lack of vitamin E leads to damage to nerve tissues and liver cells.

Hypovitaminosis of vitamin E in newborns can cause hemolytic jaundice. There is also an increased content of fat in the feces (steatorrhea), malabsorption syndrome.

Indications for the use of vitamin Alpha-tocopherol acetate

Alpha-tocopherol acetate according to the instructions is prescribed for:

muscular dystrophy (decrease in muscle strength and volume);
amyotrophic lateral sclerosis (a disease of the central nervous system, the consequence of which is a deterioration in the motor activity of the limbs and facial muscles);
myocardiopathy (disease of the heart muscle);
spasms of peripheral vessels;
liver diseases;
violations of potency (sexual activity) and violation of spermatogenesis (the process of formation of germ cells);
some types of skin diseases, including psoriasis;
failures of the menstrual cycle;
threatened miscarriage.

In pediatrics, alpha-tocopherol acetate is prescribed according to the instructions for:

malnutrition (malnutrition);
scleroderma (systemic skin disease);
hypervitaminosis D (too much vitamin D in the body).

As an antioxidant, tocopherol is used in the complex therapy of eye and cardiovascular diseases, to reduce side effects in the treatment of chemotherapy drugs.

There is evidence that tocopherol enhances the effectiveness of anticonvulsant therapy in epilepsy, in the case of an increased content of lipid peroxidation products in the blood.

Contraindications to the use of the drug

Alpha-tocopherol acetate capsules and solution should be used with caution in myocardial infarction, severe cardiosclerosis and a high risk of thromboembolism.

Method of application according to the instructions Alpha-tocopherol acetate

In diseases of the muscular and nervous system, alpha-tocopherol acetate capsules or a solution are prescribed at a dosage of 50 to 100 mg per day.

In case of violation of potency and spermatogenesis, the daily dose of Alpha-tocopherol acetate capsules or solution is from 100 to 300 mg.

With a deterioration in the condition of the embryo and habitual abortion, tocopherol is prescribed at a dosage of 100 to 150 mg per day in the first trimester of pregnancy.

With the threat of miscarriage, alpha-tocopherol acetate is prescribed according to the instructions at a dosage of 100 to 150 mg per knock for one month.

In peripheral vascular diseases and atherosclerosis, the daily dose of tocopherol is 100 mg in combination with retinol.

Side effects of the drug

When taking large doses of alpha-tocopherol acetate, performance decreases, creatinuria and diarrhea occur.