Calcemin advance tablets. Calcemin Advance: a drug for bone strength

Calcemin Advance is a combined preparation containing vitamins, micro and macro elements. Normalizes the exchange of phosphorus and calcium in the human body.

Composition of vitamins and minerals Calcemin Advance (1 tablet):

• calcium (in the form of calcium citrate tetrahydrate and calcium carbonate) - 500 mg;
• magnesium (in the form of magnesium oxide) - 40 mg;
• colecalciferol (vitamin D3) - 200 IU (international units);
• copper (in the form of copper oxide) - 1 mg;
• zinc (in the form of zinc oxide) - 7.5 mg;
• boron (in the form of sodium borate decahydrate) - 0.25 mg;
• manganese (as manganese sulfate) - 1.8 mg.

Calcium: takes part in the formation of bone tissue, increases its density and reduces resorption; strengthens joints and bone tissue; prevents the development of diseases of the musculoskeletal system;

Magnesium: is involved in protein synthesis and the formation of bone and muscle tissue;

Boron: improves calcium absorption; prevents the development of osteoporosis; reduces excess activity of PTH (parathyroid hormone); reduces the risk of developing vitamin D3 deficiency;

Zinc: necessary for the synthesis of female and male sex hormones, which has a beneficial effect on bone tissue and prevents its destruction and violation of density;

Copper: takes part in the synthesis of elastin and collagen, which are part of the connective and bone tissue, which, in turn, affects the processes of bone mass formation;

Manganese: necessary for the synthesis of proteoglycans that improve the quality of bone tissue and are involved in the formation of the collagen matrix of bone tissue;

Vitamin D3: the main element that regulates the exchange of phosphorus and calcium; enhances intestinal absorption of calcium and renal reabsorption of phosphorus; necessary for maintaining the structure of bones and the formation of the skeleton.

Calcium citrate in the composition of Calcemin Advance ensures the absorption of calcium, regardless of the functional state of the digestive system, which is applicable for the treatment of patients with reduced secretory function of the gastrointestinal tract, as well as during therapy with drugs to reduce secretion.

Indications for use

What helps Calcemin Advance? According to the instructions, the drug is prescribed for the prevention and complex therapy of osteoporosis of various origins:

• in women during menopause (natural and surgical);
• in persons taking long-term corticosteroids and immunosuppressants.

Treatment of diseases of the musculoskeletal system:

• to improve the consolidation of traumatic fractures.

Additionally, they are used to compensate for the deficiency of calcium and trace elements in adolescents.

Instructions for use Calcemin Advance, dosage

Tablets are taken orally during meals, washed down with clean water. The dosage of the drug depends on the destination.

Standard dosages for adults, according to the instructions for use of Calcemin Advance:

• Treatment of osteoporosis - 1 tablet \ 2 times a day;
• Prevention - 1 tablet \ 1 time per day;
• With a deficiency of calcium and mineral salts, the recommended dose is 1 tablet per day.

During pregnancy and lactation, take no more than 2 tablets per day. It should be borne in mind that cholecalciferol and its metabolites pass into breast milk.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Calcemin Advance:

• From the digestive system: nausea, vomiting, flatulence.
• From the side of metabolism: hypercalcemia and hypercalciuria.
• Allergic reactions are possible.

Contraindications

Calcemin Advance is contraindicated in the following cases:

• severe renal failure;
• vitamin D hypervitaminosis;
• urolithiasis disease;
• hypercalciuria;
• hypercalcemia;
• active tuberculosis;
• sarcoidosis;
• allergies to soy and peanut butter;
• age up to 12 years;
• individual intolerance to the components of the drug.

Apply with caution:

• kidney failure;
• pregnancy and breastfeeding period.

Overdose

Overdose can cause vitamin D3 hypervitaminosis, hypercalciuria and hypercalcemia.

Symptoms of an overdose are a feeling of thirst, a decrease in appetite, dizziness, nausea, headache, vomiting, fainting, muscle weakness, abdominal pain, constipation, urolithiasis, bone pain, nephrocalcinosis, polyuria, mental disorders, fatigue, coma; in severe cases - arrhythmias.

Long-term intake of calcium in a daily dose of more than 2500 mg can lead to soft tissue calcification and kidney damage.

At the first signs of an overdose, reduce the dose of Calcemin Advance or cancel it completely, and then consult a doctor. It is possible to carry out symptomatic therapy and standard measures to prevent intoxication (gastric lavage, induction of vomiting).

Patients with hypercalciuria (more than 300 mg per day) are prescribed loop diuretics, calcitonin, glucocorticosteroids, bisphosphonates, rehydration is performed, and in severe cases, hemodialysis.

Calcemin Advance analogs, price in pharmacies

If necessary, you can replace Calcemin Advance with an analogue in terms of therapeutic effect - these are drugs:

1. Vitrum Calcium with vitamin D3,
2. Calcemin,
3. Osteokea,
4. Calcium Sandoz;
5. Kaltsinova.

When choosing analogues, it is important to understand that the instructions for use of Calcemin Advance, price and reviews, do not apply to drugs of similar action. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Calcemin Advance tablets 30 pcs. - from 466 to 533 rubles, the cost of 60 tablets - from 659 to 800 rubles, according to 836 pharmacies.

Store in a place protected from moisture at temperatures up to 25 °C. Keep away from children. Shelf life - 3 years.

Terms of dispensing from pharmacies - without a prescription.

Calcemin advance is a combination drug that regulates phosphorus-calcium metabolism. Compensates for the deficiency of calcium, vitamin D3 and other trace elements - helps strengthen bones and joints, prevents diseases of the musculoskeletal system.

Calcium carbonate is the substance with the highest level of elemental calcium needed by the human body to build bone tissue.

Vitamin D3, which is part of the complex, improves the process of calcium absorption by the body, and also takes an active part in the formation of bone tissue and regeneration processes.

Zinc normalizes the production of enzymes that are necessary for the synthesis of nucleic acids and proteins. Under the influence of the microelement, the processes of tissue regeneration and the growth of new cells are stimulated.

Manganese, which is part of Calcemin Advance, stimulates the production of components that make up bone and cartilage tissues. Copper takes an active part in the formation of collagen and elastin.

Boron regulates the synthesis of parathyroid hormone - parathormone, which is necessary for calcium, magnesium and phosphorus metabolism.

Composition of Calcemin advance (1 tablet):

• calcium (in the form of calcium citrate tetrahydrate and calcium carbonate) - 500 mg;
• magnesium (in the form of magnesium oxide) - 40 mg;
• colecalciferol (vitamin D3) - 200 IU (international units);
• copper (in the form of copper oxide) - 1 mg;
• zinc (in the form of zinc oxide) - 7.5 mg;
• boron (in the form of sodium borate decahydrate) - 0.25 mg;
• manganese (as manganese sulfate) - 1.8 mg.

Clinical and pharmacological group - a drug that affects the phosphorus-calcium metabolism.

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Price in pharmacies

Information about the price of Calcemin advance in pharmacies in Russia is taken from the data of online pharmacies and may differ slightly from the price in your region.

You can buy the drug in pharmacies in Moscow at a price: Calcemin Advance tablets 60 pieces - from 643 to 681 rubles, the cost of packing 30 tablets - from 449 to 510 rubles.

Terms of dispensing from pharmacies - without a prescription.

Store in a place protected from moisture at temperatures up to 25 °C. Keep away from children. Shelf life - 3 years.

The list of analogues is presented below.

What helps Calcemin advance?

The drug Calcemin advance is prescribed in the presence of diseases of the musculoskeletal system, diseases of the teeth, as well as in diseases accompanied by loss of bone mass and impaired calcium metabolism.

Prevention and complex treatment of osteoporosis of various origins:

• in women during menopause (natural and surgical);
• in persons taking long-term corticosteroids and immunosuppressants.

Therapy of diseases of the musculoskeletal system:

• to improve the consolidation of traumatic fractures.

To compensate for the deficiency of calcium and trace elements in adolescents. Additionally, it is used to replenish the reserves of trace elements in the body during their increased need (pregnancy, lactation, fractures, intensive growth of the musculoskeletal system).

Instructions for use Calcemin advance, doses and rules

The tablet is taken orally, preferably with meals.

Standard dosages of Calcemin advance, according to the instructions for use, depending on the conditions / diseases:

• (as part of complex treatment): 2 times a day, 1 tablet, the average duration of use is 3 months;
• osteoporosis (prevention): 1 tablet once a day, the average duration of use is 2 months;
• improving the consolidation of traumatic fractures, replenishing the deficiency of trace elements and calcium in adolescents over 12 years old: 1 tablet 1 time per day, the average duration of use is 1–1.5 months.

The therapeutic effect of the treatment develops gradually, so you need to take the pills for at least 30 days. If necessary, the course of therapy is extended to 2 or more months.

Important information

With prolonged use of Calcemin, it is necessary to periodically monitor the level of calcium in the blood and urine.

The drug should not be administered simultaneously with calcium antagonists.

Patients with impaired renal function should always consult a doctor and pass the necessary tests before using the drug.

Use during pregnancy and lactation

During pregnancy and lactation, you should consult your doctor before taking Calcemin Advance.

It must be taken into account that the daily dose for pregnant women should not exceed 1500 mg of calcium and 600 IU of vitamin D3, since an overdose during pregnancy can cause defects in the physical and mental development of the child.

Colecalciferol and its metabolites are excreted in breast milk, which should be taken into account when additionally prescribing calcium and vitamin D3 to a child.

Application features

Before using the drug, read the sections of the instructions for use on contraindications, possible side effects and other important information.

Side effects of Calcemin advance

Instructions for use warns of the possibility of developing side effects of the drug Calcemin advance:

• From the digestive system: nausea, vomiting, flatulence.
• From the side of metabolism: hypercalcemia and hypercalciuria.
• Other: allergic reactions.

Contraindications

Calcemin Advance is contraindicated in the following diseases or conditions:

• urolithiasis disease;
• hypercalcemia;
• hypercalciuria;
• children's age up to 12 years;
• severe renal failure;
• vitamin D hypervitaminosis;
• allergies to soy and peanut butter;
• hypersensitivity to the components of the drug.

Assign with caution: renal failure, pregnancy and breastfeeding.

Overdose

Overdose symptoms are headache, muscle weakness, abdominal pain, diarrhea, vomiting, nausea.

With prolonged use of the drug in doses exceeding the recommended ones (more than 4000 IU / day of vitamin D and 2500 mg of calcium per day), serious toxic effects may occur, the development of renal failure, Burnett's syndrome and the development of calcification leading to nephrolithiasis.

When the first signs of an overdose appear, a reduction in the dose of the drug or its temporary cancellation is required. In case of accidental overdose, induce vomiting, rinse the stomach. If necessary, symptomatic therapy is carried out.

If hypercalciuria exceeds 7.5 mmol per day (300 mg per day), the dose of Calcemin Advance should be reduced or treatment discontinued. Recommended rehydration, the use of "loop" diuretics (for example, furosemide), glucocorticosteroids, bisphosphonates, calcitonin, in severe cases, hemodialysis is prescribed.

List of analogues Calcemin advance

If necessary, replace the drug, there are two options - choosing another drug with the same active ingredient or a drug with a similar effect, but with a different active substance. Drugs with a similar effect are united by the coincidence of the ATX code.

Analogues Calcemin advance, list of drugs:

1. Calcium Sandoz;
2. Kaltsinova;
3. Complivit;
4. Pregnavit;
5. Duovit;
6. Pikovit;
7. Vitrum;
8. Calcium D3-nycomed;
9. Multitabs.

When choosing a replacement, it is important to understand that the price, instructions for use and reviews of Calcemin Advance do not apply to analogues. Before replacing, you must obtain the approval of the attending physician and do not replace the drug yourself.

Multiple reviews speak of the widespread use of Calcemin Advance "for beauty". It is believed that the drug is well strengthened nails, teeth, hair. Doctors have extensive experience in the use of the drug for osteoporosis and fractures.

Special Information for Healthcare Professionals

Interactions

With the simultaneous use of the drug Calcemin Advance with vitamin A, the toxicity of vitamin D3 decreases.

Phenytoin, barbiturates, corticosteroids reduce the effectiveness of vitamin D3.

Laxatives reduce the absorption of vitamin D3.

GCS, hormonal contraceptives for systemic use, levothyroxine impair the absorption of calcium ions.

With the simultaneous use of tetracyclines, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is impaired) - at least 2 hours.

With the combined use of the drug Calcemin Advance with cardiac glycosides, their toxicity increases (ECG and clinical condition monitoring is necessary), with thiazide diuretics, the risk of developing hypercalcemia increases, with furosemide and other loop diuretics, calcium excretion by the kidneys increases.

Calcemin advance is a regulator of calcium phosphorus metabolism. The role of calcium in the public mind often comes down to the formation of bone tissue. But this function in the body is far from being exhausted: calcium regulates the permeability of the walls of blood vessels, the conduction of impulses through neurons, participates in contractions of skeletal muscles, and is one of the components of the blood coagulation system. Normal absorption of calcium is possible only in the presence of active alkaline phosphatase, which requires vitamin D to activate. the latter tends to accumulate in the body, which, in turn, is fraught with hypervitaminosis. Hypervitaminosis of vitamin D can cause the development of cardiovascular, nervous and hepatic pathology. In this regard, clinicians were forced to limit the duration of treatment with drugs containing vitamin D in a dose of more than 400 IU, which reduced the risk of developing hypervitaminosis, but at the same time, the effectiveness of pharmacotherapy. The latter had a negative effect on individuals with an increased need for calcium, for example, pregnant women. The way out was found by the pharmaceutical company SAGMEL. In addition to calcium and vitamin D, their Calcemin advance also contains zinc, copper, manganese and boron, which also contribute to the best absorption of calcium, which made it possible to reduce the dose of vitamin D without losing the effectiveness of treatment.

Zinc activates more than 200 enzymes, including alkaline phosphatase. Copper takes part in the formation of structural proteins of collagen and elastin, preventing a decrease in bone mineral density. Manganese ensures the normal course of the formation of mucopolysaccharides necessary for the formation of bones and cartilage. Boron controls the activity of parathyroid hormone involved in calcium phosphorus metabolism, magnesium and vitamin D metabolism. Calcemin advance is indicated in the treatment and prevention of osteoporosis (reduction in bone mass), other diseases of the musculoskeletal system associated with impaired calcium phosphorus metabolism, in adolescence - to eliminate lack of calcium and magnesium. The drug is contraindicated in case of individual intolerance to one or more components, nephrolithiasis, increased plasma calcium concentration, urinary excretion per day more than 250 (in women) and 300 (in men) mg of calcium. In pediatrics, Calcemin Advance is used from the age of 12. The frequency of admission in adults and children - twice a day. Single dose - 1 tablet. It is not recommended to exceed the dose set by the manufacturer, because. excess calcium can cause impaired absorption of iron, zinc and other trace elements. During pregnancy and breastfeeding, the drug should be taken in consultation with the doctor.

Pharmacology

Combined drug. Regulates phosphorus-calcium metabolism. Replenishes deficiency of calcium, vitamin D 3 , magnesium, microelements. Helps strengthen bones and joints, prevents diseases of the musculoskeletal system.

Pharmacokinetics

Data on the pharmacokinetics of the drug Calcemin Advance are not provided.

Release form

Pink, film-coated tablets, elongated capsule-shaped, with a notch squeezed out on one side.

Excipients: maltodextrin - 62.66 mg, microcrystalline cellulose - 50 mg, croscarmellose sodium - 38 mg, acacia - 37.96 mg, stearic acid - 16.33 mg, soy polysaccharide - 15 mg, titanium dioxide - 8.55 mg, sodium lauryl sulfate - 5 mg.

Shell composition: hypromellose (hydroxypropyl methylcellulose) - 17.47 mg, magnesium silicate - 5 mg, triacetin - 3.85 mg, mineral oil - 1.92 mg, FD&C red No. 40 varnish - 210 mcg, FD&C yellow No. 6 varnish - 53 mcg, FD&C blue No. 1 varnish - 27 mcg.

30 pcs. - polyethylene bottles (1) - cardboard packs.
60 pcs. - polyethylene bottles (1) - cardboard packs.
120 pcs. - polyethylene bottles (1) - cardboard packs.

Dosage

Adults and children (over 12 years old) - 1 tab. 2 times/day The drug is administered orally during meals.

Overdose

Symptoms: constipation, nausea and vomiting, hypercalcemia and hypercalciuria.

Treatment: drug withdrawal, symptomatic therapy.

Interaction

Data on the drug interaction of the drug Calcemin Advance is not provided.

Side effects

From the digestive system: nausea, vomiting, flatulence.

From the side of metabolism: hypercalcemia and hypercalciuria.

Other: allergic reactions.

Indications

Prevention and complex treatment of osteoporosis of various origins:

• in women during menopause (natural and surgical);
• in persons taking long-term corticosteroids and immunosuppressants.

Therapy of diseases of the musculoskeletal system:

• to improve the consolidation of traumatic fractures.

To compensate for the deficiency of calcium and trace elements in adolescents.

A drug that affects phosphorus-calcium metabolism

Active ingredients

Magnesium (as oxide) (magnesium oxide)
- copper (in oxide form)
- zinc (in the form of oxide) (zinc oxide)
- manganese (in the form of sulfate) (manganese sulfate)
- colecalciferol (vit. D 3) (colecalciferol)
- boron (in the form of sodium borate)
- calcium (in the form of citrate tetrahydrate and carbonate) (calcium carbonate)

Release form, composition and packaging

◊ Film-coated tablets pink, oval, biconvex, with a risk on one side.

Excipients: maltodextrin - 25 mg, microcrystalline cellulose - 49.05 mg, croscarmellose sodium - 38 mg, stearic acid - 16.3 mg, soy polysaccharide - 15 mg, sodium lauryl sulfate - 5 mg.

Shell composition: hypromellose - 26.328 mg, titanium dioxide - 12.643 mg, magnesium silicate - 5 mg, triacetin - 5.689 mg, mineral oil - 2.845 mg, aluminum varnish based on charming red dye (Red No. 40) - 316 mcg, aluminum varnish based on solar dye sunset yellow (Yellow No. 6) - 79 mcg, aluminum varnish based on brilliant blue dye (Blue No. 1) - 4 mcg.

30 pcs. - high-density polyethylene bottles (1) - cardboard packs.
60 pcs. - high-density polyethylene bottles (1) - cardboard packs.
120 pcs. - high-density polyethylene bottles (1) - cardboard packs.

pharmachologic effect

Combined preparation containing, micro and macro elements; the action is due to the properties that make up the ingredients.

Calcium participates in the formation of bone tissue, reduces resorption and increases bone density, prevents diseases of the musculoskeletal system, strengthens bone tissue and joints. Calcium citrate ensures the absorption of calcium, regardless of the functional state of the gastrointestinal tract, which is applicable for the treatment of patients with reduced secretory function of the gastrointestinal tract, as well as against the background of treatment with drugs to reduce secretion; reduces the level of markers of bone tissue resorption, which indicates a slowdown in the processes of bone tissue destruction; regulates the content of parathyroid hormone, which leads to improved regulation of calcium homeostasis; does not increase the content of oxalates and calcium in the urine, therefore does not cause the formation of kidney stones; does not block the absorption of iron, which reduces the risk of developing iron deficiency anemia.

Colecalciferol(vitamin D 3) regulates the metabolism of calcium and phosphorus in the body, participates in the formation of the bone skeleton, helps to preserve the structure of bones, enhances calcium absorption in the intestine and phosphorus reabsorption in the renal tubules.

Magnesium participates in the formation of muscle and bone tissues, and also takes part in protein synthesis (including type I collagen).

Zinc promotes the synthesis of sex hormones, which prevents the destruction of bone tissue. Favorably affects bone density.

Zinc and magnesium are essential for the synthesis of organic bone matrix.

Manganese participates in the formation of proteoglycans, which improves the quality of bone tissue and forms a protein (collagen) matrix of bone tissue.

Copper participates in the synthesis of collagen and elastin, which is part of the bone and connective tissue, which affects the formation of bone mass.

Bor reduces excessive activity of parathyroid hormone, improves calcium absorption, reduces the risk of developing deficiency of cholecalciferol, helps prevent osteoporosis.

Pharmacokinetics

Data on the pharmacokinetics of the drug Calcemin Advance are not provided.

Indications

Prevention and complex treatment of osteoporosis of various origins:

- in women during menopause (natural and surgical);

- in people who take GCS for a long time and.

Therapy of diseases of the musculoskeletal system:

- to improve the consolidation of traumatic fractures.

To compensate for the deficiency of calcium and trace elements in adolescents.

Contraindications

- severe renal failure;

- urolithiasis disease;

- vitamin D hypervitaminosis;

- hypercalcemia;

- hypercalciuria;

- active form of tuberculosis;

- sarcoidosis;

- children's age up to 12 years;

- Allergy to peanut butter and soy, tk. the composition of the drug includes soy polysaccharide;

- Hypersensitivity to the components of the drug.

WITH caution the drug should be prescribed for renal failure, during pregnancy and lactation.

Dosage

The drug is taken orally, during meals.

As part of complex therapy of osteoporosis appoint 1 tab. 2 times / day, with the aim prevention of osteoporosis- 1 tab. / day. The duration of the drug for the prevention of osteoporosis and in the complex therapy of osteoporosis is determined by the doctor individually. Average course duration for prevention of osteoporosis- 2 months; at treatment of osteoporosis- 3 months.

For improved consolidation of traumatic fractures appoint 1 tab. / day; the duration of treatment is 4-6 weeks.

For replenishment of calcium and microelement deficiencyteenagers from 12 years old- appoint 1 tab. / day; the average duration of treatment is 4-6 weeks.

Side effects

From the digestive system: nausea, vomiting, flatulence, diarrhea, constipation.

From the side of metabolism: hypercalcemia and hypercalciuria.

Allergic reactions: itching, rash, hives.

Overdose

An overdose of the drug can lead to vitamin D 3 hypervitaminosis, hypercalcemia and hypercalciuria.

Symptoms: thirst, polyuria, decreased appetite, constipation, nausea, vomiting, dizziness, muscle weakness, headache, fainting, coma, fatigue, bone pain, mental disorders, nephrocalcinosis, abdominal pain, urolithiasis, in severe cases - arrhythmias . With prolonged use of calcium in doses above 2500 mg - kidney damage, soft tissue calcification.

Treatment: in case of detection of the first signs of an overdose, the patient should reduce the dose or stop using the drug, consult a doctor. In case of accidental overdose, induce vomiting, gastric lavage. If necessary, carry out symptomatic therapy.

In case of hypercalciuria exceeding 7.5 mmol / day (300 mg / day), it is necessary to reduce the dose or stop taking the drug. Recommended rehydration, the use of "loop" diuretics (for example, furosemide), corticosteroids, calcitonin, bisphosphonates, in severe cases - hemodialysis.

drug interaction

With the simultaneous use of the drug Calcemin Advance A, the toxicity of vitamin D 3 decreases.

Phenytoin, barbiturates, glucocorticoids reduce the effectiveness of vitamin D 3 .

Laxatives reduce the absorption of vitamin D 3 .

Glucocorticoids, hormonal contraceptives for systemic use, levothyroxine reduce the absorption of calcium ions.

With the simultaneous use of the drug with antibiotics of the tetracycline group, the interval between doses should be at least 3 hours, with bisphosphonates and (their absorption is impaired) - at least 2 hours.

With the simultaneous use of the drug Calcemin Advance with cardiac glycosides, the toxicity of the latter increases (ECG and clinical condition monitoring is necessary).

With the simultaneous use of the drug with thiazide diuretics, the risk of developing hypercalcemia increases, with furosemide and other "loop" diuretics, the excretion of calcium by the kidneys increases.

Do not use Calcemin Advance in conjunction with.

special instructions

Influence on the ability to drive vehicles and control mechanisms

There are no data on the effect of the drug on the speed of psychomotor reactions when driving a car and working with mechanisms.

Pregnancy and lactation

During pregnancy and breastfeeding, the use of the drug must be agreed with the doctor.

The daily dose for pregnant women should not exceed 1500 mg of calcium and 600 IU of vitamin D 3, because. hypercalcemia, which develops against the background of an overdose during pregnancy, can cause defects in the mental and physical development of the child.

In lactating women, it should be borne in mind that cholecalciferol and its metabolites are excreted in breast milk. This should be taken into account when additionally prescribing calcium and vitamin D 3 to a child.

Application in childhood

The use of the drug is contraindicated in children under 12 years of age.

For impaired renal function

The use of the drug is contraindicated in severe renal failure and urolithiasis.

WITH caution the drug should be prescribed for renal failure.

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 25°C. Shelf life - 3 years.